Abstract: Hedgehog signaling plays a key role in tissue fibrosis, the pathological hallmark of chronic graft-versus-host disease (cGVHD).We conducted a phase 1 trial of sonidegib, a selective antagonist of the hedgehog coreceptor Smoothened, for the treatment of steroid-refractory cGVHD.After a 3+3 study design, sonidegib was administered for up to

One of the factors affecting the effectiveness of predatory coccinellids in an orange zinger tomato aphid infested crop is the food specificity of the predator.The response towards six species of aphids (Sternorrhyncha: Aphididae) was therefore tested in one of the most abundant aphidophagous coccinellids in Bulgaria - Propylea quatuordecimpunctata

HXN6 locomotive is a high-power AC drive hybrid diesel locomotive developed for railways in China, and it is also the largest power hybrid diesel locomotive at present.Large capacity lithium iron phosphate battery was used as power battery here for locomotive, and power supply was combined with diesel engine.The new main auxiliary drive integrated

Parry-Romberg Syndrome (PRS) is an atypical condition characterized by hemiatrophy of the face.Despite its rarity, the precise pathophysiological processes underlying its etiology remain elusive.While previous reports have hinted at the potential involvement orange zinger tomato of autoimmune factors, our case report aims to explore a novel perspec

According to Dual Systems models (Casey et al., 2008; Luna and Wright, 2016; Steinberg, 2008), a rapidly-developing socioemotional system and gradually-developing cognitive control system characterize adolescent brain development.The imbalance hypothesis forwarded by Dual Systems models posits that the magnitude of the imbalance between these two d